The Hand of Destiny is a mysterious cult consisting of five scientists that made its first appearance in Monsuno: Combat Chaos.
The Hand claims to be the rightful heirs to the original leaders of the Five Tribes of Destiny, and use gifted individuals known as "Keepers" to fuel their energy and observe events transpiring in the outside world, though the Well of Insight. The group's goal is to capture Chase Suno and steal his "Monsuno Sight".
The Hand makes and uses Shape-Shifter Cores, which copy the contents of the opponent's Core upon impact, with Shifter Lock as an example. In Monsuno Season 3, Droog developed new alien hybrid Monsunos, such as Squarx.
- Digby Droog
- Petros (transformed into children in season 3)
- Terz (transformed into children in season 3)
- Alistair (deceased)
- Christoph (deceased)
- Dasha (transformed into children in season 3)