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The series revolves around "re-awakened Monster DNA called Monsuno" that finds its way into the unsuspecting hands of adventure-seeking teenagers Chase, Jinja, and Bren. Accompanied by their Monsuno, Lock, Charger, and Quickforce, they are searching for Chase's father Jeredy Suno, the creator of the Monsuno. They are soon joined by Beyal, a monk from the Himalayas along with his Monsuno Glowblade. Beyal often speaks of five people that with the help of their Monsuno, could change the world. It just so happens that they are that five, along with Dax, a teenager who along with his Monsuno Airswitch, opposes the team and is disliked among most people. The team has yet to befriend him and persuade him to join their cause. They are also on the run from a H.A.M.M.E.R.-type agency called "S.T.O.R.M." (Strategic Tactical Operatives for Recovery of Monsuno) whose plans are still in question and Dr. Emanuel Klipse, a malevolent scientist who has his own nefarious plans.